June 1, 2006
Aubrey de Grey
Editor, Rejuvenation Research
in a lively conversation
How to Live 1,000 Years
Prospects and Reasons for
Indefinitely Extending Healthy Life
Aubrey de Grey is a biomedical gerontologist at the
University of Cambridge, England.
He is the editor of Rejuvenation
Research, the world's only peer-reviewed journal focused on intervention in aging.
His research interests encompass the etiology of all the accumulating and eventually pathogenic
molecular and cellular side-effects of metabolism
"damage" that constitute mammalian aging and the design of interventions to repair
or obviate that damage.
He has developed a possibly comprehensive plan for such repair, termed
Strategies for Engineered Negligible Senescence
(SENS), which breaks the aging problem down into seven major classes of damage and identifies detailed approaches to addressing each one.
A key aspect of SENS is that it can potentially extend healthy lifespan without limit, even though these repair processes will never be perfect, as the repair only needs to approach perfection rapidly enough to keep the overall level of damage below pathogenic levels.
De Grey has termed this required rate of improvement of repair therapies "life extension escape
Photo credit: Poppy